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96 W Main St, Northborough, MA 01532

Pain Free Pro-Nox™Nitrous Delivery System

We offer pain free and comfortable treatment at Renovo MD thanks to a system called Pro-Nox™!!

What are the Benefits of Pro-Nox™ system versus topical creams?

  • Patient is in charge of pain control. Self administered pain control in the office
  • Almost immediate relief of anxiety and pain
  • Short duration of effect
  • No downtime
  • Can drive yourself home
  • Completely Non invasive
  • FDA cleared
  • Safe and effective

Which procedures can Pro-Nox™ be used with?

The short answer is virtually any procedure as long as it’s non invasive!

Some of the procedures you can use Pro-Nox™ system at Renovo MD

  • Skin Tightening
  • NovaThreads
  • Tattoo removal
  • Kybella injections
  • CoolSculpting
  • Botox and Fillers
  • Fractional Lasers

And many more…..

What is Pro-Nox™ Nitrous delivery system?

It’s a patient self administered analgesia (pain management) not analgesia (means going to sleep). Patient never falls asleep and actually is awake and super comfortable during the procedure. The gas is inhaled, gets transferred to lungs and then gets exhaled. The half life of Nitrous oxide gas in the body is approximately 5 minutes.

The use of Nitrous oxide goes back to 1793, which is over 150 years in the history of medical field. Pro-Nox™ delivery system has allowed medical providers in cosmetic field to perform non-invasive procedures for patients with absolutely zero discomfort. It’s unique inhalation tool which allows patients to control discomfort level as well as allows the provider to have full and unobstructed access to face or body areas while performing procedures.

How does Pro-Nox™ work?

Pro-Nox™ is the same as laughing gas given to kids when they visit dentist to keep them relaxed and calm.

It’s a 50:50 mixture of gases, Nitrous oxide and Oxygen.  Nitrous Oxide allows you to feel relaxed and oxygen is keeping you breathing comfortably.

How long doe Pro-Nox™ takes to work?

Once the patient inhales a few breaths, it takes less than 20 seconds for the effect to be felt. 

How long does Pro-Nox™ effect Last?

The duration of relaxation/analgesia lasts anywhere between 3-10 minutes and varies from person to person.

What is a great advantage of Pro-Nox™?

It is unique in a sense that patient controls their discomfort level and is similar to PCA (Patient Controlled Analgesia) used in hospitals during labor and delivery, post surgery recovery units, pediatric units, dental offices, etc.

Can you drive after Pro-Nox™ treatment?

Yes, it is advisable to stay an extra 10-15 minutes after your treatment just to be certain that all gases have been out of the system. After the observation period, it is completely safe to operate any machinery.

What are the most common side effects after Pro-Nox™?

Patient may experience temporary delusions or hallucinations during the treatment, they may feel out of space or feel super relaxed like they can’t really move. They also might feel slight headache and occasionally a little nauseous. They may also feel a little dizzy or like the room is spinning. All of these are very temporary effects and go away in less than 5 minutes.

It is always recommended to have a snack and be well hydrated before any procedure, so please inform your provider if you didn’t have a chance to snack.


Once you’ve have found the treatment that you would like to receive or need to have a more specific advice, we welcome you to visit us to discuss your cosmetic goals.

Our MedSpa is Conveniently Located in Central MA

RenovoMD is located in Northborough Massachusetts and is easily accessed from Worcester, Westborough and other Central MA locations.

Licensed MD

Owner and Medical Director, Dr. Jean Casello is a leader in Massachusetts medical aesthetics and her practice offers the latest technology and services in non-invasive facial and body treatments based on “Science, Beauty and Wellness.”

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